The CB750F appeared in 1979, 10 years after the introduction of its predecessor, the CB750 Four, which was the world's first mass-produced four-cylinder motorcycle. The CB750F was so popular that 11,841 units of this large bike were sold in Japan in 1981. It is also known as the favourite motorcycle of Gun Koma, the main character of the popular motorcycle manga called Bari Bari Densetsu (Vroom Vroom Legend).

While the rival Kawasaki Z1/Z2 are already considered national treasures, the CB750F is still a significant bike in Japanese motorcycle history as it is the second generation of the 4-cylinder CB motorcycles. Although many were produced, the number of decent examples is constantly decreasing, and prices are rising accordingly. Since the appearance of the 2020 CB-F concept, CB750Fs have attracted more attention, and prices are expected to continue to rise.